Comparison of the Onset Times and Durations of Actions of Different Local Anesthetic Mixture Solutions [CODLAM]

• Status: Completed
• Trial end date: 2017-11-30
• Target enrollment: 0
• Participant gender: All

Summary

Objective To investigate the onset times and duration of local anesthetic mixture solutions used for axillary-supraclavicular brachial plexus blocks and to compare the quality of anesthesia in patients with trauma of the upper limb.

Design Randomized-prospective, observational study. Setting Perioperative, Trauma Clinic, University of Pecs, Hungary. Participants 85 consecutive, unpremedicated ASA physical status I-III patients, between the ages of 19 and 83, scheduled for trauma surgery of the hand and forearm.

Interventions Patients assigned to four groups for standardized ultrasound guided axillary-supraclavicular block with lidocaine 1% and bupivacaine 0,5% 1:1 mixture (Group LB, n = 17) or bupivacaine 0.33% (Group BS, n = 14) or lidocaine 0,66% (Group LS, n = 14) or bupivacaine 0.5% and lidocaine 1% 2:1 mixture (Group BL, n = 40). Total target volume of 0.4 ml/kg was administered to both groups.

Measurements Data were collected on patient demographics, the onset times and the duration of actions of local anesthetic mixtures were measured, the tourniquet discomfort, vital parameters, pre and postoperative verbal numeric rating scale of pain intensity, anxiolytic/analgesic consumption and the complications were recorded. The quality of anesthesia was assessed by a sensory-motor-coping-pain scale (0-16).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pecs
• Collaborator: Medical University of Pecs
• Treatments: Anesthetics; Anesthetics, Local; Bupivacaine; Lidocaine; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• elective or emergency trauma surgery of hand or forearm

• consented to ultrasound-guided BPB

Exclusion Criteria:

• continuous peripheral nerve catheter technique or bilateral block was planned

• the patient refused to participate

• psycho-mental conditions interfering with consent or assessment

• pre-existing chronic pain condition or daily analgesic or sedative consumption

• sedative or analgesic premedication

• pre-existing neurological disorders affecting the brachial plexus

• obstructive sleep apnea

• contraindications to PNB including local skin infections or allergy to LA agents.